new study in a British medical journal has stirred a passionate debate among doctors in Europe and the United States by asserting that mammograms do not prevent women from dying of breast cancer or help them avoid mastectomies.

The question is dividing experts and women's health advocates, many of whom acknowledge that they do not know what to think about the new report. For more than two decades, annual mammograms have been part of life for millions of women, with the American Cancer Society and the National Cancer Institute urging women to have them.

Experts are still digesting the new findings, which appeared in the Oct. 20 issue of the journal The Lancet, and few if any authorities in the United States are suggesting that women abandon routine mammography on the basis of this study.

Women have long been urged to have the test every year starting at age 50 or sooner, and promised that early detection will reduce their chances of dying from breast cancer by about 30 percent. And detecting cancer early, they were told, would allow women to avoid extensive surgery and harsh treatments that might be needed to control a larger tumor found later.

But the new analysis, of seven large studies of mammography conducted over the past few decades, says those promises are an illusion. It calls into question the assumption that early identification of breast tumors, before they can be felt in an external examination, improves the chances of a cure.

Those studies that found benefits from mammography were flawed, say the investigators, Dr. Peter Gotzsche, director of the Nordic Cochrane Center in Copenhagen, and Ole Olsen, the deputy director. Recent studies, more rigorously designed and conducted, found no such effects, they assert.

For example, they criticize a New York study from more than a quarter of a century ago finding that women who never had a mammogram died of breast cancer at a rate 30 percent higher than those who had the test. (Of the 30,565 who were never screened, 196 died over an 18- year period; of the 30,131 who had the test, 153 died.)

Dr. Gotzsche and Mr. Olsen say this study, and four others, do not meet agreed-upon standards for well-conducted and reliable research. They question whether the subjects who had mammograms might have been substantially healthier than those who did not, and whether deaths among women who had mammograms might be less likely to be ascribed to breast cancer than deaths among women who did not have them.

"The quality of the trials was very surprising because it is pretty low," Dr. Gotzsche said in a telephone interview. "Even if they are judged by yesterday's standards, the quality is low. In some cases, we know why that happened — these trials were conducted by people who were unfamiliar with clinical trial methodology. They were run by enthusiastic clinicians."

The researchers cite with greater approval a more recent study in Malmo, Sweden, that compared 21,088 women who had mammograms to 21,195 who served as controls. After nearly nine years, 63 women in the mammogram group had died of breast cancer, compared with 66 in the control group — an insignificant difference. The other study the researchers approved of, done in Canada, involved 44,925 women who had mammograms and 44,910 who did not. There were 120 deaths from breast cancer in the screened group and 111 among the women who served as controls.

Nor did mammography lead to fewer mastectomies, the investigators say. In the Malmo study, for example, 424 women in the mammography group and just 339 in the control group had mastectomies. One reason may be that doctors aggressively treated some tiny tumors found in mammograms — tumors that might never have developed into cancer or might never have been noticed in a woman's lifetime.

So far, just one country, Switzerland, has taken action as a result of the study, deciding not to offer a national mammography screening program. Dr. Gianfranco Domenighetti of the Swiss Network for Health Technology Assessment said the decision was heavily influenced by the Danish research.

But Switzerland did not have a national program; it was thinking of starting one. It is a different matter in a country like the United States, which has a longstanding policy of urging women to have mammograms. Once a program has been highly promoted and advanced as a way to save lives, said Dr. Barnett Kramer, the associate director for disease prevention at the National Institutes of Health, it can be difficult to suggest that guidelines be revised.

Nevertheless, some American experts, including researchers at the National Institutes of Health, say that the analysis deserves consideration, and that women should at least be aware of the debate.

But others, like experts at the American Cancer Society, say the study is unconvincing. And some advocacy groups say they are agonizing over how to advise women. They say some of their members, whose cancers were found by mammography, will always be convinced that the screening test saved their lives.

The debate has nothing to do with the effectiveness of breast cancer treatment. There is agreement that treatment, with surgery, hormones and chemotherapy, saves lives. Instead, the question — which has come up before with screening tests for other kinds of cancer — is whether earlier treatment is better.

At its heart, the analysis challenges the assumption that the period when a tumor can be seen on a mammogram but not felt in a breast examination is a critical period in which cure is possible. If that assumption is wrong — if cancers can be just as treatable, or just as deadly, whether they are found early or late — then mammography would offer no benefits.

A similar problem recently emerged with breast self-examination, another method of early detection that had been highly promoted. When studies in China and Russia indicated that it did not prevent breast cancer deaths, the cancer institute quietly dropped its emphasis on the method, saying in a database primarily for doctors that there was insufficient evidence of its value.

The institute will ask a panel of independent experts that advises it on that same database to look at the new mammography study, said Dr. Peter Greenwald, the institute's director for cancer prevention.

Dr. Greenwald added that there might be a simple explanation for the discrepancy among the studies analyzed by the researchers in Copenhagen. Newer treatments are saving women's lives, he said. That may mean that a woman's prognosis is nearly the same whether tumors are found early, with mammography, or later, when they can be felt. If this is the case, earlier mammography studies, conducted when treatments were less effective, would have found that screening prevents breast cancer deaths; more recent studies might not have found this effect.

But the most important question, Dr. Gotzsche said, is not whether women are saved from dying of breast cancer; it is whether mammograms prolong their lives. It is possible, he said, that a mammogram might find a cancer early, leading to treatment that might prevent a breast cancer death. But theoretically, the treatment might be so harsh that it precipitates another illness, so that the woman lives no longer, although her death is not attributed to breast cancer.

No one study was large enough to answer that question, so the investigators combined study data. They concluded that the overall death rate did not budge when women had mammograms compared with when they did not.

Dr. Greenwald said that while he had not formed an opinion about the validity of the analysis, he considered the study "important." But other experts, like Dr. David Freedman, a statistician at the University of California at Berkeley, dismiss it as deeply flawed. Dr. Freedman said some of the studies Dr. Gotzsche and Mr. Olsen cite as weak were actually the strongest, and vice versa. He called Dr. Gotzsche "incredibly alert to all difficulties in work he doesn't like" but added, "In papers he does like, he swallows anything."

Dr. Freedman said it would be ridiculous to demand evidence that mammography lowers the overall death rate. The reason, he said, is that breast cancer accounts for only 1 to 3 percent of deaths among women, making it impossible to see such an effect even if lives are saved.

"Mammography is not like aspirin and headache," he said. "The evidence is complicated. But the advice I would give someone is to get screened."

Dr. Robert A. Smith, the director of the division of cancer screening at the American Cancer Society, defended the studies criticized by the investigators in Denmark. "The trials have been gone over with a very, very critical eye by a lot of people," he said. "Although people differ in terms of which ones they prefer, most people would never have dismissed five out of seven as unworthy of consideration."

Dr. Smith said the cancer society would examine the new report as part of a previously scheduled review of publications on mammography. But, he said, "I do not see anything in the Olsen and Gotzsche analysis that would lead the review committee to question the evidence and wisdom of routine screening mammography for women 40 and older."

Dr. Stephen A. Feig, a radiologist who directs breast imaging at Mount Sinai School of Medicine in New York, said, "Screening has weathered controversies before and it will continue to do so."

Health insurance companies usually pay for mammograms. Joseph Luchok, a spokesman for the Health Insurance Association of America said, "If a procedure is covered it would stay covered until the medical community came to the opinion that it is not a useful procedure."

But some doctors who want to advise their patients confess that they are whipsawed by the dueling experts. "The debate has become so sophisticated from a methodology viewpoint that as a doctor my head is spinning," said Dr. Barron H. Lerner, an internist and historian at Columbia University's College of Physicians and Surgeons. Dr. Lerner wrote "Breast Cancer Wars" (Oxford University Press, 2001).

"You read the article in The Lancet and you nod your head yes. Then you read the studies by people on the other side and you nod your head yes," Dr. Lerner said. "We're witnessing this fight between the pro- and anti-mammography forces and they're both arguing that `my data is better and we're right and they're wrong.' "

What should be done, Dr. Lerner said, is "sitting back and trying to analyze how we as patients, as doctors, as a society, should deal with these conflicting data."

That is an issue that is plaguing some advocacy groups.

The report "is really causing a huge amount of concern among activists," said Cindy Pearson, the executive director of the National Women's Health Network. She said her group no longer advocates self- examination. Now, she said, if mammograms are not useful, "you're just left out there with nothing."

Fran Visco, president of the National Breast Cancer Coalition, said she welcomed the mammography dispute. "We know that mammography screening has serious limitations, yet it has been sold as the be-all and end-all for breast cancer," Ms. Visco said. "When someone says, `We have to question that assumption,' we're thrilled. We've been questioning it from the beginning."

"I'm not ready to tell women over 50 not to get screened," Ms. Visco said. "But what we are telling women is that we don't have a good screening test to detect breast cancer early and we're not sure what to do when we find it early." It is time, she said, to focus on these issues rather than assume that mammograms are the answer.

Jenny Thompson over Mammografie

Bron: Jenny Thompson
Health Sciences Institute

Last year, an analysis of all available mammography research by two
scientists at the Nordic Cochrane Center in Copenhagen, Denmark concluded,
"screening for breast cancer with mammography is unjustified." The Cochrane
Center is well known and respected in the medical research community for its
rigorous systematic review methods. In this thorough review of seven of the
largest mammography studies from around the world, the Cochrane scientists
found that "there is no reliable evidence that screening decreases breast
cancer mortality." The study was met with solid resistance and sharp
criticism. The medical community effectively covered its ears as if to say,
"I'm not listening!" After all, think about how many women they've sent to
have this test. They needed to believe they had been doing the right thing.

Now, those same authors are back with another study. In response to the
heckling they endured last year, they re-examined their data and subjected
it to even more rigorous analysis. This time the results are even harder to
ignore.

As the authors stated in a research letter in the British medical journal
The Lancet, the second analysis just "confirmed and strengthened" their
previous findings. They still found no benefit from mammograms. In fact,
they found that they may actually be harmful, as women who were screened
with mammograms were much more likely to undergo a mastectomy, lumpectomy,
or radiation treatment. And according to their evidence, these invasive
procedures did little to save women's lives,- and may actually put them in
harm's way.

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Mortality rates show no overall decline with screening
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How can this be? For two decades now they've been telling us that regular
mammograms allow women to catch cancer early, while it's still easily
treated. Women over 40 are told to get a mammogram every year - and millions
of women have been dutifully following that advice.

The authors say the recommendations are based on flawed studies and flawed
logic. Previously published studies showing a benefit from mammography were
poorly designed and incorrectly interpreted. Many showed a reduction in
deaths from breast cancer, while failing to show a reduction in deaths
overall - a discrepancy that didn't make a lot of sense. When the authors
dug further, they found the studies often misclassified the cause of death
with a bias in favor of mammograms. When studies used overall mortality as
the main outcome measure, they failed to find any benefit from screening.

They also question the assumption that mammograms catch tumors during a
small and critical window of treatment opportunity. The entire screening
theory is based on the supposition that if you detect cancers while they are
still too small to be felt, they can be cured. But in reality, the authors
say there is little evidence to support that.

They point to two studies that support their position. The first, conducted
in Malmo, Sweden, compared the experience of 21,088 women who had mammograms
to 21,095 women who did not. After nearly nine years, 63 women in the
mammogram group and 66 women in the control group had died of breast cancer.
The second study, performed in Canada, tracked 44,925 women who had
mammograms and 44,910 controls. Among this group, 120 of the screened women
died of breast cancer, while 111 women in the control group died of the
disease.

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Screening increases surgeries by 30 percent
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Proponents of early screening have also claimed that it can reduce the need
for surgery, as smaller tumors found earlier could be treated in other ways.
But this claim didn't bear out in reality. The researchers found that women
who underwent regular screening had about 30 percent more mastectomies and
lumpectomies than women who weren't screened. They also found that tumors
detected by mammograms are likely to be treated with radiation, which
carries a real risk of cardiovascular damage. As the authors wrote, "as
screening primarily seems to identify slow-growing tumors, the adverse
effects of treatment could potentially reduce or even neutralize any
possible benefits."

According to the New York Times, this study has lead Swiss officials to
abandon plans to offer a national mammography screening program. But so far,
the rest of the world is still covering its ears. Officials at the American
Cancer Society dubbed the study "unconvincing." They plan to continue to
tell women to get regular mammograms each year, and to spout their mantra
that mammograms save lives.

None of us should assume that a yearly mammogram will save us from breast
cancer - or that surgery and radiation are the only acceptable responses to
a positive reading. As this study shows, there are many more variables to
consider and many more assumptions to challenge before jumping on the
mainstream bandwagon. If nothing else, you should insist that your doctor
consider this analysis before ordering annual mammograms.

To Your Good Health,

Jenny Thompson
Health Sciences Institute

De Volkskrant over Mammografie

Het onderstaande artikel stond in de Volkskrant van 17 november, maar daar is bij mijn weten geen vervolgdiscussie op gekomen of actie ondernomen om de screening te veranderen of te laten vervallen.. Nog steeds worden duizenden vrouwen gescreend met mammografie, hoewel nu tientallen studies hebben bewezen dat deze totaal zinloos zijn en geen enkel effect hebben op overlevingskansen

Van onze verslaggever Marc van den Broek

Het massaal oproepen van vrouwen tussen de 50 en 75 jaar voor een borstkankeronderzoek heeft geen zin. Door het vroegtijdig opsporen van de tumor neemt de sterfte aan deze kankersoort niet af. Dit schrijven twee artsen in het Nederlands Tijdschrift voor Geneeskunde dat vandaag verschijnt.

'Er zijn zo weinig argumenten voor het bevolkingsonderzoek en er zijn zoveel bijwerkingen en schadelijke effecten dat ik geen reden zie om het voort te zetten', zegt dr. R. Giard, een van de auteurs, verbonden aan het Erasmus Medisch Centrum te Rotterdam.

Het bevolkingsonderzoek naar borstkanker is landelijk ingevoerd aan het einde van de jaren tachtig. Om de twee jaar krijgt elke vrouw tussen de 50 en 75 een oproep om een röntgenfoto van de borsten te laten maken. Tachtig procent komt op, jaarlijks zo'n zevenhonderd- tot achthonderdduizend vrouwen. Hiervan wordt 1 procent doorgestuurd. De helft van de verwijzingen is terecht. Elk onderzoek kost honderd gulden, de zeventig- tot tachtig miljoen die jaarlijks met het onderzoek is gemoeid, wordt betaald uit de algemene middelen.

Twee Deense onderzoekers hebben gegevens over bevolkingsonderzoeken naar borstkanker op een rij gezet en concludeerden dat er geen effect op de sterfte is. De studies, die dat effect wel aantonen, zijn methodologisch niet goed. De resultaten verschenen vorige maand in het gezaghebbende Engelse medische tijdschrift The Lancet, waarna een discussie over het nut van bevolkingsonderzoeken is begonnen.

Giard is ervan overtuigd dat de screening niets uitmaakt. Er worden vroegtijdig tumoren opgespoord die snel worden geholpen, terwijl niet goed bekend is wat er gebeurt als je niets doet. De behandeling is niet zonder risico bijvoorbeeld op hart- en vaatziekten.

'In de statistieken vinden we geen voordeel van de vroege opsporing.' Hij vindt dat de vrouwen op een eerlijkere manier moeten worden voorgelicht over de screening.

De coördinatiecommissie borstkankeronderzoek, die de minister adviseert over de screening, zegt bij monde van secretaris P. Romijn dat er geen reden is om het standpunt over screening te veranderen. 'Wij zien een daling van de sterfte door borstkanker.' Dat wordt bevestigd door arts-onderzoeker J. Fracheboud van de commissie. 'Maar wij weten niet hoe het komt. We vinden het aannemelijk dat screening voor een groot deel verantwoordelijk is voor de daling. We kunnen echter niet bewijzen dat de screening de sterfte verlaagt.'

Fracheboud heeft wel kritiek op het Deense onderzoek. Volgens hem hebben de Denen zich gebaseerd op relatief kleine en nogal oude studies uit Scandinavië, waar ook vrouwen onder de 50 zijn opgeroepen voor de screening. Maar de arts, verbonden aan de Erasmus-universiteit, vindt het terecht om kritisch te kijken naar het bevolkingsonderzoek naar borstkanker. 'Je moet stoppen als het onderzoek geen zin heeft.